| 9/4/2021 | Texas A&M-Kingsville | 9 | at | Saginaw Valley State (7-4) | 13 | at GLIAC | ||
| 9/11/2021 | Western Oregon (4-6) | 10 | at | Texas A&M-Kingsville | 24 | GNWAC | ||
| 9/18/2021 | Texas A&M-Kingsville | 36 | at | Eastern New Mexico (4-7,1-6) | 10 | |||
| 9/25/2021 | Texas A&M-Commerce (7-4,5-2) | 35 | at | Texas A&M-Kingsville | 10 | |||
| 10/9/2021 | Texas A&M-Kingsville | 13 | at | Midwestern State (7-3,6-1) | 30 | |||
| 10/16/2021 | Lincoln CA (1-9) | 21 | at | Texas A&M-Kingsville | 51 | None (Unk?) | ||
| 10/23/2021 | Texas A&M-Kingsville | 28 | at | Western New Mexico (1-9,0-7) | 19 | |||
| 10/30/2021 | West Texas A&M (7-4,5-2) | 35 | at | Texas A&M-Kingsville | 23 | |||
| 11/6/2021 | Texas A&M-Kingsville | 29 | at | Texas-Permian Basin (5-6,3-4) | 22 | |||
| 11/13/2021 | Angelo State (11-3,5-2) | 58 | at | Texas A&M-Kingsville | 19 |
| vs Texas A&M-Kingsville | vs Other Opponents | Texas A&M-Kingsville compared to OOs | |
| Record: | 5-5 | 49-50 | |
| Points Scored: | 25.30 | 27.87 | 2.57 |
| Points Allowed: | 24.20 | 27.97 | -3.77 |
| Margin: | 1.10 | -0.10 | -1.20 |
| Total Points: | 49.50 | 55.84 | -6.34 |