| 9/5/2021 | Tennessee State (5-6) | 10 | vs | Grambling | 16 | Canton OH | OVC | |
| 9/11/2021 | Grambling | 0 | at | Southern Miss (3-9) | 37 | at CUSA | ||
| 9/18/2021 | Grambling | 0 | at | Houston (12-2) | 45 | at AAC | ||
| 9/25/2021 | Grambling | 10 | vs | Prairie View (7-5,6-3) | 24 | Dallas TX | ||
| 10/2/2021 | Alabama A&M (7-3,5-3) | 28 | at | Grambling | 37 | |||
| 10/9/2021 | Grambling | 20 | at | Alcorn State (6-5,5-3) | 24 | |||
| 10/16/2021 | Texas Southern (3-8,2-6) | 20 | at | Grambling | 34 | |||
| 10/30/2021 | Grambling | 3 | at | Florida A&M (9-3,7-1) | 26 | |||
| 11/6/2021 | Grambling | 26 | at | Ark Pine Bluff (2-9,1-7) | 33 | |||
| 11/13/2021 | Bethune-Cookman (2-9,2-6) | 31 | at | Grambling | 14 | |||
| 11/27/2021 | Southern (4-7,3-5) | 26 | vs | Grambling | 29 | New Orleans LA |
| vs Grambling | vs Other Opponents | Grambling compared to OOs | |
| Record: | 7-4 | 53-62 | |
| Points Scored: | 27.64 | 26.67 | -0.97 |
| Points Allowed: | 17.18 | 29.84 | -12.66 |
| Margin: | 10.46 | -3.17 | -13.63 |
| Total Points: | 44.82 | 56.51 | -11.69 |