| 9/3/2021 | South Dakota (7-5) | 14 | at | Kansas | 17 | MVC (1AA) | ||
| 9/10/2021 | Kansas | 22 | at | Coastal Carolina (11-2) | 49 | at SBC | ||
| 9/18/2021 | Baylor (12-2,8-2) | 45 | at | Kansas | 7 | |||
| 9/25/2021 | Kansas | 33 | at | Duke (3-9) | 52 | at ACC | ||
| 10/2/2021 | Kansas | 7 | at | Iowa State (7-6,5-4) | 59 | |||
| 10/16/2021 | Texas Tech (7-6,3-6) | 41 | at | Kansas | 14 | |||
| 10/23/2021 | Oklahoma (11-2,7-2) | 35 | at | Kansas | 23 | |||
| 10/30/2021 | Kansas | 3 | at | Oklahoma State (12-2,8-2) | 55 | |||
| 11/6/2021 | Kansas State (8-5,4-5) | 35 | at | Kansas | 10 | |||
| 11/13/2021 | Kansas | 57 | at | Texas (5-7,3-6) | 56 | OT | ||
| 11/20/2021 | Kansas | 28 | at | TCU (5-7,3-6) | 31 | |||
| 11/27/2021 | West Virginia (6-7,4-5) | 34 | at | Kansas | 28 |
| vs Kansas | vs Other Opponents | Kansas compared to OOs | |
| Record: | 10-2 | 84-58 | |
| Points Scored: | 42.17 | 30.03 | -12.14 |
| Points Allowed: | 20.75 | 25.60 | -4.85 |
| Margin: | 21.42 | 4.43 | -16.99 |
| Total Points: | 62.92 | 55.63 | 7.29 |