| 9/4/2021 | Missouri State (8-4) | 16 | at | Oklahoma State | 23 | MVC (1AA) | ||
| 9/11/2021 | Tulsa (7-6) | 23 | at | Oklahoma State | 28 | AAC | ||
| 9/18/2021 | Oklahoma State | 21 | at | Boise State (7-5) | 20 | at MW | ||
| 9/25/2021 | Kansas State (8-5,4-5) | 20 | at | Oklahoma State | 31 | |||
| 10/2/2021 | Baylor (12-2,8-2) | 14 | at | Oklahoma State | 24 | |||
| 10/16/2021 | Oklahoma State | 32 | at | Texas (5-7,3-6) | 24 | |||
| 10/23/2021 | Oklahoma State | 21 | at | Iowa State (7-6,5-4) | 24 | |||
| 10/30/2021 | Kansas (2-10,1-8) | 3 | at | Oklahoma State | 55 | |||
| 11/6/2021 | Oklahoma State | 24 | at | West Virginia (6-7,4-5) | 3 | |||
| 11/13/2021 | TCU (5-7,3-6) | 17 | at | Oklahoma State | 63 | |||
| 11/20/2021 | Oklahoma State | 23 | at | Texas Tech (7-6,3-6) | 0 | |||
| 11/27/2021 | Oklahoma (11-2,7-2) | 33 | at | Oklahoma State | 37 | |||
| 12/4/2021 | Baylor (12-2,8-2) | 21 | vs | Oklahoma State | 16 | Big XII Championship - Arlington TX | ||
| 1/1/2022 | Oklahoma State | 37 | vs | Notre Dame (11-2) | 35 | Fiesta Bowl - Glendale AZ | vs ND |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 2-12 | 105-58 | |
| Points Scored: | 18.07 | 31.94 | 13.87 |
| Points Allowed: | 31.07 | 25.13 | 5.94 |
| Margin: | -13.00 | 6.81 | 19.81 |
| Total Points: | 49.14 | 57.07 | -7.93 |