| 9/3/2021 | North Carolina (6-7,4-5) | 10 | at | Virginia Tech | 17 | |||
| 9/11/2021 | Middle Tenn State (7-6) | 14 | at | Virginia Tech | 35 | CUSA | ||
| 9/18/2021 | Virginia Tech | 21 | at | West Virginia (6-7) | 27 | at B12 | ||
| 9/25/2021 | Richmond (6-5) | 10 | at | Virginia Tech | 21 | CAAF (1AA) | ||
| 10/9/2021 | Notre Dame (11-2) | 32 | at | Virginia Tech | 29 | ND | ||
| 10/16/2021 | Pittsburgh (11-3,8-1) | 28 | at | Virginia Tech | 7 | |||
| 10/23/2021 | Syracuse (5-7,2-6) | 41 | at | Virginia Tech | 36 | |||
| 10/30/2021 | Virginia Tech | 26 | at | Georgia Tech (3-9,2-6) | 17 | |||
| 11/5/2021 | Virginia Tech | 3 | at | Boston College (6-6,2-6) | 17 | |||
| 11/13/2021 | Duke (3-9,0-8) | 17 | at | Virginia Tech | 48 | |||
| 11/20/2021 | Virginia Tech | 26 | at | Miami-Florida (7-5,5-3) | 38 | |||
| 11/27/2021 | Virginia Tech | 29 | at | Virginia (6-6,4-4) | 24 | |||
| 12/29/2021 | Maryland (7-6) | 54 | vs | Virginia Tech | 10 | Pinstribe Bowl - Bronx NY | B10 |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 7-6 | 77-72 | |
| Points Scored: | 25.31 | 30.26 | 4.95 |
| Points Allowed: | 23.69 | 27.81 | -4.12 |
| Margin: | 1.62 | 2.45 | 0.83 |
| Total Points: | 49.00 | 58.07 | -9.07 |