| 8/28/2021 | Nebraska (3-9,1-8) | 22 | at | Illinois | 30 | |||
| 9/4/2021 | Texas-San Antonio (12-2) | 37 | at | Illinois | 30 | CUSA | ||
| 9/11/2021 | Illinois | 14 | at | Virginia (6-6) | 42 | at ACC | ||
| 9/17/2021 | Maryland (7-6,3-6) | 20 | at | Illinois | 17 | |||
| 9/25/2021 | Illinois | 9 | at | Purdue (9-4,6-3) | 13 | |||
| 10/2/2021 | UNC-Charlotte (5-7) | 14 | at | Illinois | 24 | CUSA | ||
| 10/9/2021 | Wisconsin (9-4,6-3) | 24 | at | Illinois | 0 | |||
| 10/23/2021 | Illinois | 20 | at | Penn State (7-6,4-5) | 18 | 9OT | ||
| 10/30/2021 | Rutgers (5-8,2-7) | 20 | at | Illinois | 14 | |||
| 11/6/2021 | Illinois | 14 | at | Minnesota (9-4,6-3) | 6 | |||
| 11/20/2021 | Illinois | 23 | at | Iowa (10-4,7-3) | 33 | |||
| 11/27/2021 | Northwestern (3-9,1-8) | 14 | at | Illinois | 47 |
| vs Illinois | vs Other Opponents | Illinois compared to OOs | |
| Record: | 7-5 | 78-64 | |
| Points Scored: | 21.92 | 27.16 | 5.24 |
| Points Allowed: | 20.17 | 24.40 | -4.23 |
| Margin: | 1.75 | 2.76 | 1.01 |
| Total Points: | 42.09 | 51.56 | -9.47 |