| 9/2/2021 | UC Davis (8-4) | 19 | at | Tulsa | 17 | BSky (1AA) | ||
| 9/11/2021 | Tulsa | 23 | at | Oklahoma State (12-2) | 28 | at B12 | ||
| 9/18/2021 | Tulsa | 20 | at | Ohio State (11-2) | 41 | at B10 | ||
| 9/25/2021 | Arkansas State (2-10) | 34 | at | Tulsa | 41 | SBC | ||
| 10/1/2021 | Houston (12-2,8-1) | 45 | at | Tulsa | 10 | |||
| 10/9/2021 | Memphis (6-6,3-5) | 29 | at | Tulsa | 35 | |||
| 10/16/2021 | Tulsa | 32 | at | South Florida (2-10,1-7) | 31 | |||
| 10/29/2021 | Navy (4-8,3-5) | 20 | at | Tulsa | 17 | |||
| 11/6/2021 | Tulsa | 20 | at | Cincinnati (13-1,9-0) | 28 | |||
| 11/13/2021 | Tulsa | 20 | at | Tulane (2-10,1-7) | 13 | OT | ||
| 11/20/2021 | Temple (3-9,1-7) | 10 | at | Tulsa | 44 | |||
| 11/27/2021 | Tulsa | 34 | at | SMU (8-4,4-4) | 31 | |||
| 12/20/2021 | Old Dominion (6-7) | 17 | vs | Tulsa | 30 | Myrtle Beach Bowl - Conway SC | CUSA |
| vs Tulsa | vs Other Opponents | Tulsa compared to OOs | |
| Record: | 6-7 | 83-68 | |
| Points Scored: | 26.62 | 30.27 | 3.65 |
| Points Allowed: | 26.38 | 27.35 | -0.97 |
| Margin: | 0.24 | 2.92 | 2.68 |
| Total Points: | 53.00 | 57.62 | -4.62 |