| 9/4/2021 | Cortland (11-1) | 38 | at | Wittenberg | 16 | E8 | ||
| 9/18/2021 | Hiram (1-9,0-9) | 21 | at | Wittenberg | 51 | |||
| 9/25/2021 | Wittenberg | 16 | at | Denison (6-4,6-3) | 21 | |||
| 10/2/2021 | Wittenberg | 24 | at | Ohio Wesleyan (8-2,7-2) | 23 | |||
| 10/9/2021 | DePauw (9-3,8-1) | 17 | at | Wittenberg | 14 | |||
| 10/16/2021 | Wittenberg | 44 | at | Oberlin (1-9,1-8) | 27 | |||
| 10/23/2021 | Kenyon (3-7,3-6) | 14 | at | Wittenberg | 38 | |||
| 10/30/2021 | Wittenberg | 29 | at | Allegheny (3-7,2-7) | 19 | |||
| 11/6/2021 | Wittenberg | 35 | at | Wabash (7-3,6-3) | 14 | |||
| 11/13/2021 | Wooster (6-4,5-4) | 29 | at | Wittenberg | 44 |
| vs Wittenberg | vs Other Opponents | Wittenberg compared to OOs | |
| Record: | 3-7 | 52-42 | |
| Points Scored: | 22.30 | 31.16 | 8.86 |
| Points Allowed: | 31.10 | 27.77 | 3.33 |
| Margin: | -8.80 | 3.39 | 12.19 |
| Total Points: | 53.40 | 58.93 | -5.53 |