| 9/2/2021 | Millsaps | 28 | at | Belhaven | 56 | SAA | ||
| East Texas Baptist | 37 | at | Wisconsin-Platteville | 31 | @ WIAC | |||
| 9/4/2021 | Southwestern Texas | 7 | at | Cal Lutheran | 37 | @ SCIAC | ||
| Wayland Baptist | 0 | at | Hardin-Simmons | 49 | Soon (NAIA) | |||
| Texas Lutheran | 17 | at | Howard Payne | 43 | ||||
| Simpson | 6 | at | Mary Hardin-Baylor | 84 | ARC | |||
| McMurry | at | Trinity TX | Canceled COVID | @ SAA | ||||
| 9/11/2021 | Southwestern Texas | 34 | at | Belhaven | 27 | |||
| East Texas Baptist | 14 | at | Mary Hardin-Baylor | 34 | ||||
| Howard Payne | 42 | at | McMurry | 36 | ||||
| Hardin-Simmons | 27 | at | Sul Ross State | 0 | ||||
| Austin | 7 | at | Texas Lutheran | 41 | SAA | |||
| 9/18/2021 | Sul Ross State | 7 | at | Austin | 16 | @ SAA | ||
| McMurry | 15 | at | East Texas Baptist | 24 | ||||
| Belhaven | 16 | at | Hardin-Simmons | 21 | ||||
| Hendrix | 21 | vs | Howard Payne | 55 | Prosper TX | vs SAA | ||
| Mary Hardin-Baylor | 54 | at | Southwestern Texas | 3 | ||||
| Trinity TX | 51 | at | Texas Lutheran | 14 | SAA | |||
| 9/25/2021 | Austin | 14 | at | Belhaven | 41 | SAA | ||
| Howard Payne | 49 | at | East Texas Baptist | 38 | ||||
| Hardin-Simmons | 28 | at | Mary Hardin-Baylor | 34 | ||||
| Southwestern Texas | 31 | at | McMurry | 41 | ||||
| Texas Lutheran | 10 | at | Sul Ross State | 12 | ||||
| 10/2/2021 | Mary Hardin-Baylor | 56 | at | Austin | 0 | @ SAA | ||
| McMurry | 21 | at | Hardin-Simmons | 24 | ||||
| Sul Ross State | 30 | at | Howard Payne | 73 | ||||
| East Texas Baptist | 27 | at | Southwestern Texas | 17 | ||||
| Belhaven | 42 | at | Texas Lutheran | 35 | ||||
| 10/9/2021 | North American U | 44 | at | Sul Ross State | 37 | Exhibition | None (Unk?) | |
| 10/16/2021 | Sul Ross State | 0 | at | Belhaven | 44 | |||
| Hardin-Simmons | 34 | at | East Texas Baptist | 0 | ||||
| Texas Lutheran | 3 | at | Mary Hardin-Baylor | 49 | ||||
| Austin | 13 | at | McMurry | 48 | SAA | |||
| Howard Payne | 21 | at | Southwestern Texas | 17 | ||||
| 10/23/2021 | East Texas Baptist | 37 | at | Austin | 30 | @ SAA | ||
| Southwestern Texas | 7 | at | Hardin-Simmons | 69 | ||||
| Belhaven | 24 | at | Howard Payne | 10 | ||||
| Mary Hardin-Baylor | 72 | at | Sul Ross State | 14 | ||||
| McMurry | 21 | at | Texas Lutheran | 28 | ||||
| 10/30/2021 | Texas Lutheran | 20 | at | East Texas Baptist | 13 | |||
| Hardin-Simmons | 38 | at | Howard Payne | 14 | ||||
| Belhaven | 0 | at | Mary Hardin-Baylor | 29 | ||||
| Sul Ross State | 24 | at | McMurry | 11 | ||||
| Austin | 19 | at | Southwestern Texas | 45 | SAA | |||
| 11/6/2021 | Hardin-Simmons | 56 | at | Austin | 14 | @ SAA | ||
| McMurry | 20 | at | Belhaven | 35 | ||||
| Howard Payne | 14 | at | Mary Hardin-Baylor | 59 | ||||
| East Texas Baptist | 31 | at | Sul Ross State | 28 | ||||
| Southwestern Texas | 24 | at | Texas Lutheran | 14 | ||||
| 11/13/2021 | Belhaven | 41 | at | East Texas Baptist | 7 | |||
| Texas Lutheran | 0 | at | Hardin-Simmons | 65 | ||||
| Austin | 21 | at | Howard Payne | 49 | SAA | |||
| Mary Hardin-Baylor | 77 | at | McMurry | 3 | ||||
| Sul Ross State | 15 | at | Southwestern Texas | 49 | ||||
| 11/20/2021 | Trinity TX | 3 | at | Mary Hardin-Baylor | 13 | SAA | ||
| 11/27/2021 | Birmingham-Southern | 7 | at | Mary Hardin-Baylor | 42 | SAA | ||
| 12/4/2021 | Linfield | 24 | at | Mary Hardin-Baylor | 49 | NWC | ||
| 12/11/2021 | Mary Hardin-Baylor | 24 | at | Wisconsin-Whitewater | 7 | D3 Semifinal | @ WIAC | |
| 12/17/2021 | Mary Hardin-Baylor | 57 | vs | North Central | 24 | D3 Championship - Canton OH | vs CCIW |