| 9/2/2021 | East Texas Baptist (5-5) | 37 | at | Wisconsin-Platteville | 31 | ASWC | ||
| 9/11/2021 | Wisconsin-Platteville | 7 | at | Bethel MN (8-3) | 28 | at MIA | ||
| 9/18/2021 | Wisconsin-Platteville | 44 | at | Franklin (6-4) | 19 | at HCA | ||
| 10/2/2021 | Wisconsin-Oshkosh (6-3,4-3) | 35 | at | Wisconsin-Platteville | 32 | |||
| 10/9/2021 | Wisconsin-Platteville | 21 | at | Wisconsin-Whitewater (13-1,7-0) | 65 | |||
| 10/16/2021 | Wisconsin-La Crosse (9-3,6-1) | 24 | at | Wisconsin-Platteville | 23 | |||
| 10/23/2021 | Wisconsin-Stevens Point (2-8,0-8) | 21 | at | Wisconsin-Platteville | 45 | |||
| 10/30/2021 | Wisconsin-Platteville | 28 | at | Wisconsin-River Falls (9-2,5-2) | 31 | |||
| 11/6/2021 | Wisconsin-Platteville | 55 | at | Wisconsin-Eau Claire (3-7,1-6) | 28 | |||
| 11/13/2021 | Wisconsin-Stout (5-5,3-5) | 28 | at | Wisconsin-Platteville | 35 |
| vs Wisconsin-Platteville | vs Other Opponents | Wisconsin-Platteville compared to OOs | |
| Record: | 6-4 | 60-37 | |
| Points Scored: | 31.60 | 32.26 | 0.66 |
| Points Allowed: | 32.10 | 24.74 | 7.36 |
| Margin: | -0.50 | 7.52 | 8.02 |
| Total Points: | 63.70 | 57.00 | 6.70 |