| 9/1/2018 | Texas-Permian Basin (2-9) | 16 | at | Texas Southern | 26 | LSC (D2) | ||
| 9/8/2018 | Texas Southern | 20 | at | Texas State (3-9) | 36 | at SBC | ||
| 9/15/2018 | Texas Southern | 15 | at | Alcorn State (9-4,8-1) | 27 | |||
| 9/22/2018 | Texas Southern | 14 | at | Houston (8-5) | 70 | at AAC | ||
| 10/6/2018 | Alabama A&M (6-5,5-3) | 42 | at | Texas Southern | 21 | |||
| 10/13/2018 | Grambling (6-5,5-3) | 34 | at | Texas Southern | 21 | |||
| 10/20/2018 | Texas Southern | 7 | vs | Southern (7-4,6-2) | 21 | Dallas TX | ||
| 10/27/2018 | Mississippi Valley State (1-10,1-6) | 14 | at | Texas Southern | 42 | |||
| 11/3/2018 | Texas Southern | 21 | at | Alabama State (4-7,3-4) | 30 | |||
| 11/17/2018 | Ark Pine Bluff (2-9,1-6) | 15 | at | Texas Southern | 10 | |||
| 11/24/2018 | Texas Southern | 14 | at | Prairie View (5-6,4-3) | 60 |
| vs Texas Southern | vs Other Opponents | Texas Southern compared to OOs | |
| Record: | 9-2 | 44-71 | |
| Points Scored: | 33.18 | 26.62 | -6.56 |
| Points Allowed: | 19.18 | 31.83 | -12.65 |
| Margin: | 14.00 | -5.21 | -19.21 |
| Total Points: | 52.36 | 58.45 | -6.09 |