| 8/30/2018 | Mississippi Valley State | 7 | at | North Dakota (6-5) | 35 | at Ind1AA | ||
| 9/8/2018 | Mississippi Valley State | 0 | at | Jacksonville State (9-4) | 71 | at OVC | ||
| 9/22/2018 | Alcorn State (9-4,8-1) | 56 | at | Mississippi Valley State | 20 | |||
| 10/6/2018 | Mississippi Valley State | 27 | at | Bethune-Cookman (7-5) | 41 | at MEAC | ||
| 10/13/2018 | Mississippi Valley State | 7 | at | Jackson State (5-5,4-3) | 23 | |||
| 10/20/2018 | Ark Pine Bluff (2-9,1-6) | 47 | at | Mississippi Valley State | 48 | 2OT | ||
| 10/27/2018 | Mississippi Valley State | 14 | at | Texas Southern (2-9,1-7) | 42 | |||
| 11/3/2018 | Mississippi Valley State | 19 | at | Grambling (6-5,5-3) | 24 | |||
| 11/10/2018 | Hampton (7-3) | 54 | at | Mississippi Valley State | 39 | Ind1AA | ||
| 11/17/2018 | Alabama A&M (6-5,5-3) | 42 | at | Mississippi Valley State | 14 | |||
| 11/22/2018 | Mississippi Valley State | 24 | at | Alabama State (4-7,3-4) | 31 | OT |
| vs Mississippi Valley State | vs Other Opponents | Mississippi Valley State compared to OOs | |
| Record: | 10-1 | 53-60 | |
| Points Scored: | 42.36 | 25.95 | -16.41 |
| Points Allowed: | 19.91 | 29.25 | -9.34 |
| Margin: | 22.45 | -3.30 | -25.75 |
| Total Points: | 62.27 | 55.20 | 7.07 |