| 8/25/2018 | Prairie View | 28 | at | Rice (2-11) | 31 | at CUSA | ||
| 9/2/2018 | Prairie View | 40 | vs | North Carolina Central (5-6) | 24 | Atlanta GA | vs MEAC | |
| 9/8/2018 | Prairie View | 32 | at | Sam Houston (6-5) | 41 | at SLC | ||
| 9/15/2018 | Prairie View | 17 | at | UNLV (4-8) | 46 | at MW | ||
| 9/22/2018 | Prairie View | 62 | at | Ark Pine Bluff (2-9,1-6) | 13 | |||
| 9/29/2018 | Prairie View | 22 | vs | Grambling (6-5,5-3) | 16 | Dallas TX | ||
| 10/13/2018 | Southern (7-4,6-2) | 38 | at | Prairie View | 0 | |||
| 10/27/2018 | Alcorn State (9-4,8-1) | 27 | at | Prairie View | 13 | |||
| 11/3/2018 | Prairie View | 28 | at | Jackson State (5-5,4-3) | 34 | |||
| 11/17/2018 | Alabama State (4-7,3-4) | 13 | at | Prairie View | 66 | |||
| 11/24/2018 | Texas Southern (2-9,1-7) | 14 | at | Prairie View | 60 |
| vs Prairie View | vs Other Opponents | Prairie View compared to OOs | |
| Record: | 6-5 | 46-68 | |
| Points Scored: | 27.00 | 24.52 | -2.48 |
| Points Allowed: | 33.45 | 30.84 | 2.61 |
| Margin: | -6.45 | -6.32 | 0.13 |
| Total Points: | 60.45 | 55.36 | 5.09 |