| 8/30/2018 | Eastern New Mexico | 14 | at | Missouri S&T | 31 | @ GLV | ||
| Texas A&M-Kingsville | 36 | at | Texas A&M-Commerce | 37 | 2OT | |||
| Delta State | 13 | at | Tarleton State | 44 | GSC | |||
| 9/1/2018 | West Texas A&M | 7 | at | Azusa Pacific | 17 | @ GNWAC | ||
| Humboldt State | 12 | at | Midwestern State | 55 | GNWAC | |||
| Western New Mexico | 9 | at | San Diego | 38 | @ Pio (1AA) | |||
| Texas-Permian Basin | 16 | at | Texas Southern | 26 | @ SWAC (1AA) | |||
| Angelo State | 24 | at | Western Oregon | 17 | @ GNWAC | |||
| 9/8/2018 | Angelo State | 24 | at | Abilene Christian | 41 | @ SLC (1AA) | ||
| Colorado Mesa | 34 | at | Eastern New Mexico | 21 | RMAC | |||
| Western New Mexico | 10 | at | Idaho | 56 | @ BSky (1AA) | |||
| West Florida | 17 | at | Midwestern State | 38 | GSC | |||
| Texas-Permian Basin | 22 | at | Northern Michigan | 27 | @ GLIAC | |||
| Tarleton State | at | Stephen F. Austin | CCD | @ SLC (1AA) | ||||
| Texas Wesleyan | 10 | at | Texas A&M-Kingsville | 52 | Soon (NAIA) | |||
| Panhandle State | 7 | at | West Texas A&M | 42 | Soon (NAIA) | |||
| Texas A&M-Commerce | 27 | at | William Jewell | 17 | @ GLV | |||
| 9/15/2018 | Texas A&M-Kingsville | 14 | at | Angelo State | 30 | |||
| Texas A&M-Commerce | 21 | at | Eastern New Mexico | 11 | ||||
| Midwestern State | 43 | at | Texas-Permian Basin | 21 | ||||
| Tarleton State | 44 | at | West Texas A&M | 7 | ||||
| 9/22/2018 | Angelo State | 36 | at | Midwestern State | 57 | |||
| Colorado State-Pueblo | 23 | at | Texas A&M-Commerce | 13 | RMAC | |||
| Eastern New Mexico | 31 | at | Texas A&M-Kingsville | 14 | ||||
| Texas-Permian Basin | 13 | at | Tarleton State | 35 | ||||
| West Texas A&M | 27 | at | Western New Mexico | 17 | ||||
| 9/29/2018 | Tarleton State | 54 | at | Angelo State | 33 | |||
| West Texas A&M | 28 | at | Central Washington | 26 | @ GNWAC | |||
| Midwestern State | 31 | at | Eastern New Mexico | 23 | ||||
| Lock Haven | 6 | at | Texas A&M-Commerce | 68 | PSAC | |||
| New Mexico Highlands | 30 | at | Texas A&M-Kingsville | 33 | RMAC | |||
| Western New Mexico | 20 | at | Texas-Permian Basin | 21 | ||||
| 10/6/2018 | Texas A&M-Commerce | at | Midwestern State | CCD | ||||
| Western Oregon | 13 | at | Texas A&M-Kingsville | 7 | GNWAC | |||
| Eastern New Mexico | 28 | at | Tarleton State | 48 | ||||
| Texas-Permian Basin | 21 | at | West Texas A&M | 42 | ||||
| Angelo State | 52 | at | Western New Mexico | 0 | ||||
| 10/7/2018 | Texas A&M-Commerce | 20 | vs | Midwestern State | 19 | Wichita Falls TX/Denton TX | ||
| 10/13/2018 | West Texas A&M | 26 | at | Angelo State | 18 | |||
| Western New Mexico | 9 | at | Eastern New Mexico | 55 | ||||
| Tarleton State | 47 | at | Texas A&M-Commerce | 21 | ||||
| Midwestern State | 69 | at | Texas A&M-Kingsville | 14 | ||||
| Humboldt State | 17 | at | Texas-Permian Basin | 36 | GNWAC | |||
| 10/20/2018 | Texas A&M-Kingsville | 21 | at | Tarleton State | 59 | |||
| Angelo State | 44 | at | Texas-Permian Basin | 20 | ||||
| Eastern New Mexico | 28 | at | West Texas A&M | 0 | ||||
| Texas A&M-Commerce | 55 | at | Western New Mexico | 7 | ||||
| 10/27/2018 | Adams State | 20 | at | Angelo State | 59 | RMAC | ||
| Texas-Permian Basin | 7 | at | Eastern New Mexico | 24 | ||||
| Tarleton State | 35 | at | Midwestern State | 34 | OT | |||
| West Texas A&M | 16 | at | Texas A&M-Commerce | 41 | ||||
| Western New Mexico | 34 | at | Texas A&M-Kingsville | 37 | ||||
| 11/3/2018 | Eastern New Mexico | 17 | at | Angelo State | 34 | |||
| Lincoln MO | 3 | at | Tarleton State | 59 | GLV | |||
| Texas A&M-Commerce | 20 | at | Texas-Permian Basin | 17 | ||||
| Texas A&M-Kingsville | 31 | at | West Texas A&M | 35 | ||||
| Midwestern State | 48 | at | Western New Mexico | 35 | ||||
| 11/10/2018 | Western Oregon | 14 | at | Eastern New Mexico | 19 | GNWAC | ||
| West Texas A&M | 23 | at | Midwestern State | 24 | OT | |||
| Angelo State | 13 | at | Texas A&M-Commerce | 41 | ||||
| Texas-Permian Basin | 21 | at | Texas A&M-Kingsville | 24 | ||||
| Western New Mexico | 0 | at | Tarleton State | 58 | ||||
| 11/17/2018 | Texas A&M-Commerce | 33 | at | Minnesota-Duluth | 17 | D2 Playoff Round 1 | @ NSIC | |
| Azusa Pacific | 0 | at | Tarleton State | 58 | D2 Playoff Round 1 | GNWAC | ||
| 11/24/2018 | Texas A&M-Commerce | 28 | at | Tarleton State | 34 | |||
| 12/1/2018 | Central Oklahoma | 41 | vs | Angelo State | 34 | Waco TX | vs MAIAA | |
| Tarleton State | 10 | at | Minnesota State-Mankato | 13 | D2 Playoff | @ NSIC |