| 9/1/2018 | Kansas Wesleyan (13-1) | 42 | at | Texas Wesleyan | 7 | KCAC | ||
| 9/8/2018 | Texas Wesleyan | 10 | at | Texas A&M-Kingsville (4-7) | 52 | at LSC | ||
| 9/15/2018 | Texas College (1-7,1-7) | 7 | at | Texas Wesleyan | 36 | |||
| 9/22/2018 | Texas Wesleyan | 29 | at | Arizona Christian (7-3,5-3) | 36 | |||
| 10/6/2018 | Langston (8-2,8-0) | 55 | at | Texas Wesleyan | 31 | |||
| 10/13/2018 | Panhandle State (6-5,6-2) | 49 | at | Texas Wesleyan | 25 | |||
| 10/20/2018 | Texas Wesleyan | 46 | at | Southwestern Assemblies of God (5-5,4-4) | 53 | |||
| 10/27/2018 | Texas Wesleyan | 30 | at | Wayland Baptist (4-5,3-5) | 41 | |||
| 11/3/2018 | Lyon (3-7,2-6) | 20 | at | Texas Wesleyan | 21 | |||
| 11/10/2018 | Ottawa AZ (5-4,5-3) | 35 | at | Texas Wesleyan | 29 |
| vs Texas Wesleyan | vs Other Opponents | Texas Wesleyan compared to OOs | |
| Record: | 8-2 | 48-44 | |
| Points Scored: | 39.00 | 33.66 | -5.34 |
| Points Allowed: | 26.40 | 31.86 | -5.46 |
| Margin: | 12.60 | 1.80 | -10.80 |
| Total Points: | 65.40 | 65.52 | -0.12 |