| 8/30/2018 | Central Oklahoma | 7 | at | Pittsburg State (8-3,8-3) | 21 | | | |
| 9/6/2018 | Nebraska-Kearney (5-6,5-6) | 31 | at | Central Oklahoma | 27 | | | |
| 9/15/2018 | Central Oklahoma | 52 | at | Lindenwood (4-7,4-7) | 42 | | | |
| 9/22/2018 | Northwest Missouri State (10-3,9-2) | 21 | at | Central Oklahoma | 31 | | | |
| 9/29/2018 | Central Oklahoma | 0 | at | Fort Hays State (9-3,9-2) | 15 | | | |
| 10/6/2018 | Central Missouri (5-6,5-6) | 26 | at | Central Oklahoma | 33 | | | |
| 10/13/2018 | Central Oklahoma | 17 | at | Missouri Western (7-5,6-5) | 16 | | | |
| 10/20/2018 | Washburn (5-6,5-6) | 0 | at | Central Oklahoma | 34 | | | |
| 10/27/2018 | Central Oklahoma | 31 | at | Missouri Southern (1-10,1-10) | 0 | | | |
| 11/3/2018 | Central Oklahoma | 62 | at | Northeastern State (0-11,0-11) | 0 | | | |
| 11/10/2018 | Emporia State (8-4,7-4) | 35 | at | Central Oklahoma | 28 | | | |
| 12/1/2018 | Central Oklahoma | 41 | vs | Angelo State (6-6) | 34 | | Waco TX | vs LSC |