| 9/1/2018 | Hastings (5-6) | 26 | at | Panhandle State | 17 | GPAC | ||
| 9/8/2018 | Panhandle State | 7 | at | West Texas A&M (6-5) | 42 | at LSC | ||
| 9/15/2018 | Panhandle State | 38 | at | Ottawa AZ (5-4,5-3) | 35 | |||
| 9/22/2018 | Wayland Baptist (4-5,3-5) | 17 | at | Panhandle State | 20 | |||
| 9/29/2018 | Panhandle State | 16 | at | Lyon (3-7,2-6) | 29 | |||
| 10/6/2018 | Panhandle State | 7 | at | Grambling (6-5) | 62 | at SWAC | ||
| 10/13/2018 | Panhandle State | 49 | at | Texas Wesleyan (2-8,2-6) | 25 | |||
| 10/20/2018 | Arizona Christian (7-3,5-3) | 14 | at | Panhandle State | 21 | |||
| 10/27/2018 | Panhandle State | 35 | at | Southwestern Assemblies of God (5-5,4-4) | 20 | |||
| 11/3/2018 | Texas College (1-7,1-7) | 0 | at | Panhandle State | 42 | |||
| 11/10/2018 | Panhandle State | 9 | at | Langston (8-2,8-0) | 33 |
| vs Panhandle State | vs Other Opponents | Panhandle State compared to OOs | |
| Record: | 5-6 | 47-51 | |
| Points Scored: | 27.55 | 30.94 | 3.39 |
| Points Allowed: | 23.73 | 33.41 | -9.68 |
| Margin: | 3.82 | -2.47 | -6.29 |
| Total Points: | 51.28 | 64.35 | -13.07 |