| 9/4/2016 | Notre Dame | 47 | at | Texas | 50 | 2OT | @ B12 | |
| 9/10/2016 | Nevada | 10 | at | Notre Dame | 39 | MW | ||
| 9/17/2016 | Michigan State | 36 | at | Notre Dame | 28 | B10 | ||
| 9/24/2016 | Duke | 38 | at | Notre Dame | 35 | ACC | ||
| 10/1/2016 | Notre Dame | 50 | vs | Syracuse | 33 | East Rutherford NJ | vs ACC | |
| 10/8/2016 | Notre Dame | 3 | at | North Carolina State | 10 | @ ACC | ||
| 10/15/2016 | Stanford | 17 | at | Notre Dame | 10 | P12 | ||
| 10/29/2016 | Miami-Florida | 27 | at | Notre Dame | 30 | ACC | ||
| 11/5/2016 | Notre Dame | 27 | vs | Navy | 28 | Jacksonville FL | vs AAC | |
| 11/12/2016 | Army | 6 | vs | Notre Dame | 44 | San Antonio TX | vs Ind | |
| 11/19/2016 | Virginia Tech | 34 | at | Notre Dame | 31 | ACC | ||
| 11/26/2016 | Notre Dame | 27 | at | Southern California | 45 | @ P12 |