| 9/1/2016 | West Texas A&M | 10 | at | Azusa Pacific | 28 | @ GNWAC | ||
| Angelo State | 19 | at | McKendree | 33 | @ GLV | |||
| Eastern New Mexico | 35 | at | Southwest Baptist | 49 | @ GLV | |||
| 9/3/2016 | Texas A&M-Kingsville | 31 | at | Incarnate Word | 22 | @ SLC (1AA) | ||
| Tarleton State | 3 | at | McNeese State | 33 | @ SLC (1AA) | |||
| Panhandle State | 21 | at | Sam Houston | 59 | @ SLC (1AA) | |||
| Sul Ross State | 6 | at | Texas-Permian Basin | 27 | ASWC (D3) | |||
| Midwestern State | 31 | at | Truman State | 19 | @ GLV | |||
| 9/10/2016 | Panhandle State | 20 | at | Ark Pine Bluff | 16 | @ SWAC (1AA) | ||
| West Texas A&M | 26 | at | Colorado State-Pueblo | 10 | @ RMAC | |||
| Texas A&M-Commerce | 40 | at | Delta State | 28 | @ GSC | |||
| Western New Mexico | 16 | at | Eastern New Mexico | 37 | RMAC | |||
| Angelo State | 47 | at | Northern Michigan | 41 | 3OT | @ GLIAC | ||
| Simon Fraser | 7 | at | Texas A&M-Kingsville | 68 | GNWAC | |||
| Southwest Baptist | 31 | at | Tarleton State | 28 | GLV | |||
| Arizona Christian | 34 | at | Texas-Permian Basin | 49 | CSFL (NAIA) | |||
| 9/17/2016 | Texas A&M-Commerce | 49 | at | Eastern New Mexico | 10 | |||
| Midwestern State | 32 | at | Texas A&M-Kingsville | 30 | ||||
| Angelo State | 5 | at | Tarleton State | 35 | ||||
| Panhandle State | 21 | at | Western New Mexico | 44 | @ RMAC | |||
| 9/18/2016 | West Texas A&M | 48 | at | Texas-Permian Basin | 14 | |||
| 9/24/2016 | Eastern New Mexico | 25 | at | Angelo State | 14 | |||
| Texas A&M-Kingsville | 36 | at | Texas A&M-Commerce | 38 | ||||
| Western New Mexico | 68 | at | Texas-Permian Basin | 17 | RMAC | |||
| Tarleton State | 25 | at | West Texas A&M | 37 | ||||
| 9/25/2016 | Panhandle State | 24 | at | Midwestern State | 42 | |||
| 10/1/2016 | West Texas A&M | 30 | at | Eastern New Mexico | 39 | |||
| Texas A&M-Commerce | 35 | at | Panhandle State | 13 | ||||
| Angelo State | 22 | at | Texas A&M-Kingsville | 21 | ||||
| Texas-Permian Basin | 20 | at | Tarleton State | 48 | ||||
| Midwestern State | 43 | at | Western New Mexico | 22 | @ RMAC | |||
| 10/8/2016 | Panhandle State | 9 | at | Angelo State | 31 | |||
| Midwestern State | 26 | at | Texas A&M-Commerce | 25 | ||||
| Western New Mexico | 41 | at | Tarleton State | 44 | RMAC | |||
| Eastern New Mexico | 34 | at | Texas-Permian Basin | 3 | ||||
| Texas A&M-Kingsville | 51 | at | West Texas A&M | 34 | ||||
| 10/15/2016 | Tarleton State | 26 | at | Eastern New Mexico | 16 | |||
| Angelo State | 21 | at | Midwestern State | 28 | ||||
| West Texas A&M | 42 | at | Panhandle State | 14 | ||||
| Texas-Permian Basin | 7 | at | Texas A&M-Kingsville | 56 | ||||
| Texas A&M-Commerce | 38 | at | Western New Mexico | 24 | @ RMAC | |||
| 10/22/2016 | Texas A&M-Commerce | 62 | at | Angelo State | 14 | |||
| Bacone | 0 | at | Eastern New Mexico | 62 | CSFL (NAIA) | |||
| Texas A&M-Kingsville | 21 | at | Tarleton State | 17 | ||||
| Panhandle State | 54 | at | Texas-Permian Basin | 44 | ||||
| Midwestern State | 27 | at | West Texas A&M | 35 | ||||
| 10/29/2016 | Texas-Permian Basin | 21 | at | Midwestern State | 76 | |||
| Tarleton State | 45 | at | Panhandle State | 26 | ||||
| West Texas A&M | 0 | at | Texas A&M-Commerce | 36 | ||||
| Eastern New Mexico | 28 | at | Texas A&M-Kingsville | 41 | ||||
| Angelo State | 14 | at | Western New Mexico | 20 | @ RMAC | |||
| 11/5/2016 | Panhandle State | 10 | at | Eastern New Mexico | 53 | |||
| Western New Mexico | 13 | at | Texas A&M-Kingsville | 28 | RMAC | |||
| Midwestern State | 21 | at | Tarleton State | 16 | ||||
| Texas A&M-Commerce | 58 | at | Texas-Permian Basin | 21 | ||||
| Angelo State | 28 | at | West Texas A&M | 6 | ||||
| 11/12/2016 | Texas-Permian Basin | 21 | at | Angelo State | 70 | |||
| Eastern New Mexico | 30 | at | Midwestern State | 28 | ||||
| Texas A&M-Kingsville | 53 | at | Panhandle State | 39 | ||||
| Tarleton State | 10 | at | Texas A&M-Commerce | 30 | ||||
| West Texas A&M | 37 | at | Western New Mexico | 30 | @ RMAC | |||
| 11/19/2016 | Midwestern State | 34 | at | Ferris State | 65 | @ GLIAC | ||
| Colorado Mesa | 23 | at | Texas A&M-Commerce | 34 | RMAC | |||
| 11/26/2016 | Texas A&M-Commerce | 32 | at | Grand Valley State | 55 | @ GLIAC | ||
| 12/3/2016 | Eastern New Mexico | 12 | at | Fort Hays State | 45 | ? | @ MAIAA | |
| Texas A&M-Kingsville | 24 | vs | Southern Arkansas | 17 | Texarkana TX | vs GAC |