| 9/3/2016 | Tarleton State (5-6) | 3 | at | McNeese State | 33 | LSC (D2) | ||
| 9/10/2016 | McNeese State | 22 | at | UL Lafayette (6-7) | 30 | at SBC | ||
| 9/17/2016 | Stephen F. Austin (5-6,4-5) | 31 | at | McNeese State | 28 | |||
| 9/24/2016 | McNeese State | 42 | at | Incarnate Word (3-8,3-6) | 35 | |||
| 10/1/2016 | Nicholls State (5-6,5-4) | 13 | at | McNeese State | 38 | |||
| 10/8/2016 | McNeese State | 24 | at | Southeastern Louisiana (7-4,7-2) | 31 | |||
| 10/15/2016 | Central Arkansas (10-3,8-1) | 35 | at | McNeese State | 0 | |||
| 10/22/2016 | McNeese State | 48 | at | Northwestern State (1-10,0-9) | 27 | |||
| 10/29/2016 | Abilene Christian (2-9,2-7) | 14 | at | McNeese State | 33 | |||
| 11/5/2016 | McNeese State | 43 | at | Sam Houston (12-1,9-0) | 56 | |||
| 11/19/2016 | Lamar (3-8,3-6) | 10 | at | McNeese State | 41 |
| vs McNeese State | vs Other Opponents | McNeese State compared to OOs | |
| Record: | 5-6 | 54-62 | |
| Points Scored: | 25.91 | 29.68 | 3.77 |
| Points Allowed: | 32.00 | 30.53 | 1.47 |
| Margin: | -6.09 | -0.85 | 5.24 |
| Total Points: | 57.91 | 60.21 | -2.30 |