| 9/1/2016 | Angelo State (5-6) | 19 | at | McKendree | 33 | LSC | ||
| 9/10/2016 | West Liberty (4-7) | 15 | at | McKendree | 16 | OT | MtnE | |
| 9/17/2016 | McKendree | 16 | at | Drake (7-4) | 28 | at Pio | ||
| 9/24/2016 | William Jewell (1-9,1-7) | 14 | at | McKendree | 28 | |||
| 10/1/2016 | McKendree | 7 | at | Southwest Baptist (10-2,7-1) | 35 | |||
| 10/8/2016 | McKendree | 24 | at | Indianapolis (6-5,5-3) | 34 | |||
| 10/15/2016 | St Joseph's (5-6,3-5) | 16 | at | McKendree | 20 | |||
| 10/22/2016 | Missouri S&T (5-6,4-4) | 7 | at | McKendree | 40 | |||
| 10/29/2016 | McKendree | 55 | at | Lincoln MO (1-10,0-8) | 3 | |||
| 11/5/2016 | McKendree | 35 | at | Quincy (5-6,3-5) | 17 | |||
| 11/12/2016 | Truman State (8-3,7-1) | 14 | at | McKendree | 41 |
| vs McKendree | vs Other Opponents | McKendree compared to OOs | |
| Record: | 3-8 | 54-56 | |
| Points Scored: | 18.36 | 27.67 | 9.31 |
| Points Allowed: | 28.64 | 27.68 | 0.96 |
| Margin: | -10.28 | -0.01 | 10.27 |
| Total Points: | 47.00 | 55.35 | -8.35 |