| 9/3/2016 | Panhandle State (2-9) | 21 | at | Sam Houston | 59 | LSC (D2) | ||
| 9/17/2016 | Sam Houston | 44 | at | Lamar (3-8,3-6) | 31 | |||
| 9/24/2016 | Sam Houston | 52 | at | Houston Baptist (4-7,3-5) | 16 | |||
| 10/1/2016 | Stephen F. Austin (5-6,4-5) | 28 | vs | Sam Houston | 63 | Houston TX | ||
| 10/8/2016 | Sam Houston | 63 | at | Incarnate Word (3-8,3-6) | 48 | |||
| 10/15/2016 | Abilene Christian (2-9,2-7) | 21 | at | Sam Houston | 48 | |||
| 10/22/2016 | Sam Houston | 38 | at | Nicholls State (5-6,5-4) | 21 | |||
| 10/29/2016 | Texas Southern (4-7) | 17 | at | Sam Houston | 66 | SWAC | ||
| 11/5/2016 | McNeese State (6-5,5-4) | 43 | at | Sam Houston | 56 | |||
| 11/12/2016 | Sam Houston | 48 | at | Northwestern State (1-10,0-9) | 16 | |||
| 11/19/2016 | Central Arkansas (10-3,8-1) | 23 | at | Sam Houston | 59 | |||
| 12/3/2016 | Chattanooga (9-4) | 36 | at | Sam Houston | 41 | 1AA Playoffs | SoCon | |
| 12/9/2016 | Sam Houston | 7 | at | James Madison (14-1) | 65 | 1AA Quarterfinals | at CAAF |
| vs Sam Houston | vs Other Opponents | Sam Houston compared to OOs | |
| Record: | 1-12 | 67-71 | |
| Points Scored: | 29.69 | 28.88 | -0.81 |
| Points Allowed: | 49.54 | 28.51 | 21.03 |
| Margin: | -19.85 | 0.37 | 20.22 |
| Total Points: | 79.23 | 57.39 | 21.84 |