| 9/3/2016 | East Tennessee St | 20 | at | Kennesaw St | 17 | 2OT | @ BigS | |
| Coastal Carolina | 38 | at | Lamar | 14 | @ SLC | |||
| 9/10/2016 | Florida A&M | 10 | at | Coastal Carolina | 49 | MEAC | ||
| 9/17/2016 | Western Carolina | 31 | at | East Tennessee St | 34 | SoCon | ||
| Coastal Carolina | 26 | at | Jacksonville State | 27 | @ OVC | |||
| 9/24/2016 | Furman | 21 | at | Coastal Carolina | 41 | SoCon | ||
| East Tennessee St | 0 | at | Wofford | 31 | @ SoCon | |||
| 10/1/2016 | Charleston Southern | 59 | at | Coastal Carolina | 58 | 2OT | BigS | |
| Chattanooga | 37 | at | East Tennessee St | 7 | SoCon | |||
| 10/8/2016 | East Tennessee St | 7 | at | VMI | 37 | @ SoCon | ||
| 10/15/2016 | Furman | 52 | at | East Tennessee St | 7 | SoCon | ||
| Coastal Carolina | 17 | at | Gardner-Webb | 7 | @ BigS | |||
| 10/20/2016 | West Virginia Wesleyan | 7 | at | East Tennessee St | 38 | MtnE (D2) | ||
| 10/22/2016 | Central Conn | 25 | at | Coastal Carolina | 33 | NE | ||
| 10/29/2016 | Coastal Carolina | 48 | at | Presbyterian | 17 | @ BigS | ||
| East Tennessee St | 10 | at | The Citadel | 45 | @ SoCon | |||
| 11/5/2016 | Monmouth NJ | 17 | at | Coastal Carolina | 38 | BigS | ||
| East Tennessee St | 13 | at | Mercer | 21 | @ SoCon | |||
| 11/12/2016 | Bryant | 21 | at | Coastal Carolina | 31 | NE | ||
| Cumberland TN | 16 | at | East Tennessee St | 23 | MSC (NAIA) | |||
| 11/17/2016 | Liberty | 7 | at | Coastal Carolina | 42 | BigS | ||
| 11/19/2016 | Samford | 14 | at | East Tennessee St | 15 | SoCon | ||
| 11/26/2016 | Hampton | 7 | at | Coastal Carolina | 26 | MEAC |