| 9/3/2016 | West Virginia Wesleyan | 12 | at | Shepherd (13-1,10-0) | 27 | |||
| 9/10/2016 | Glenville State (5-6,5-5) | 31 | at | West Virginia Wesleyan | 28 | |||
| 9/17/2016 | West Virginia Wesleyan | 35 | at | West Virginia State (3-8,3-7) | 14 | |||
| 9/24/2016 | Concord (2-9,2-8) | 20 | at | West Virginia Wesleyan | 17 | |||
| 9/29/2016 | West Virginia Wesleyan | 24 | at | West Liberty (4-7,4-6) | 28 | |||
| 10/8/2016 | Fairmont State (10-2,9-1) | 31 | at | West Virginia Wesleyan | 17 | |||
| 10/15/2016 | West Virginia Wesleyan | 21 | at | Urbana (3-8,2-8) | 20 | |||
| 10/20/2016 | West Virginia Wesleyan | 7 | at | East Tennessee St (5-6) | 38 | at IndFCS | ||
| 10/29/2016 | Charleston WV (3-8,3-7) | 25 | at | West Virginia Wesleyan | 27 | |||
| 11/5/2016 | West Virginia Wesleyan | 35 | at | Virginia-Wise (6-5,5-5) | 10 | |||
| 11/12/2016 | Notre Dame OH (9-2,8-2) | 26 | at | West Virginia Wesleyan | 21 |
| vs West Virginia Wesleyan | vs Other Opponents | West Virginia Wesleyan compared to OOs | |
| Record: | 7-4 | 56-58 | |
| Points Scored: | 24.55 | 25.96 | 1.41 |
| Points Allowed: | 22.18 | 27.25 | -5.07 |
| Margin: | 2.37 | -1.29 | -3.66 |
| Total Points: | 46.73 | 53.21 | -6.48 |