| 9/4/2010 | Memphis | 7 | @ | Mississippi State | 49 | ||||
| 9/11/2010 | Memphis | 27 | @ | East Carolina | 49 | CUSA | |||
| 9/18/2010 | Middle Tenn State | 17 | @ | Memphis | 24 | ||||
| 9/25/2010 | Memphis | 13 | @ | UTEP | 16 | CUSA | |||
| 10/2/2010 | Tulsa | 48 | @ | Memphis | 7 | CUSA | |||
| 10/9/2010 | Memphis | 0 | @ | Louisville | 56 | ||||
| 10/16/2010 | Southern Miss | 41 | @ | Memphis | 19 | CUSA | |||
| 10/30/2010 | Houston | 56 | @ | Memphis | 17 | CUSA | |||
| 11/6/2010 | Tennessee | 50 | @ | Memphis | 14 | ||||
| 11/13/2010 | Memphis | 13 | @ | Marshall | 28 | CUSA | |||
| 11/20/2010 | Memphis | 15 | @ | UAB | 31 | CUSA | |||
| 11/27/2010 | UCF | 37 | @ | Memphis | 17 | CUSA |