| 9/5/2010 | SMU | 27 | @ | Texas Tech | 35 | ||||
| 9/11/2010 | UAB | 7 | @ | SMU | 28 | CUSA | |||
| 9/18/2010 | Washington State | 21 | @ | SMU | 35 | ||||
| 9/24/2010 | TCU | 41 | @ | SMU | 24 | ||||
| 10/2/2010 | SMU | 42 | @ | Rice | 31 | CUSA | |||
| 10/9/2010 | Tulsa | 18 | @ | SMU | 21 | CUSA | |||
| 10/16/2010 | SMU | 21 | @ | Navy | 28 | ||||
| 10/23/2010 | Houston | 45 | @ | SMU | 20 | CUSA | |||
| 10/30/2010 | SMU | 31 | @ | Tulane | 17 | CUSA | |||
| 11/6/2010 | SMU | 14 | @ | UTEP | 28 | CUSA | |||
| 11/20/2010 | Marshall | 17 | @ | SMU | 31 | CUSA | |||
| 11/26/2010 | SMU | 45 | @ | East Carolina | 38 | OT | CUSA | ||
| 12/4/2010 | SMU | 7 | @ | UCF | 17 | CUSA | CUSA Championship | ||
| 12/30/2010 | Army | 16 | vs | SMU | 14 | Fort Worth - Armed Forces Bowl |