| 9/4/2010 | Western Carolina 1AA | 7 | @ | North Carolina State | 48 | ||||
| 9/11/2010 | North Carolina State | 28 | @ | UCF | 21 | ||||
| 9/16/2010 | Cincinnati | 19 | @ | North Carolina State | 30 | ||||
| 9/25/2010 | North Carolina State | 45 | @ | Georgia Tech | 28 | ACC | |||
| 10/2/2010 | Virginia Tech | 41 | @ | North Carolina State | 30 | ACC | |||
| 10/9/2010 | Boston College | 17 | @ | North Carolina State | 44 | ACC | |||
| 10/16/2010 | North Carolina State | 27 | @ | East Carolina | 33 | OT | |||
| 10/28/2010 | Florida State | 24 | @ | North Carolina State | 28 | ACC | |||
| 11/6/2010 | North Carolina State | 13 | @ | Clemson | 14 | ACC | |||
| 11/13/2010 | Wake Forest | 3 | @ | North Carolina State | 38 | ACC | |||
| 11/20/2010 | North Carolina State | 29 | @ | North Carolina | 25 | ACC | |||
| 11/27/2010 | North Carolina State | 31 | @ | Maryland | 38 | ACC | |||
| 12/28/2010 | West Virginia | 7 | vs | North Carolina State | 23 | Orlando - Champs Sports Bowl |