| 9/4/2010 | Texas State 1AA | 28 | @ | Houston | 68 | ||||
| 9/10/2010 | UTEP | 24 | @ | Houston | 54 | CUSA | |||
| 9/18/2010 | Houston | 13 | @ | UCLA | 31 | ||||
| 9/25/2010 | Tulane | 23 | @ | Houston | 42 | CUSA | |||
| 10/9/2010 | Mississippi State | 47 | @ | Houston | 24 | ||||
| 10/16/2010 | Houston | 31 | @ | Rice | 34 | CUSA | |||
| 10/23/2010 | Houston | 45 | @ | SMU | 20 | CUSA | |||
| 10/30/2010 | Houston | 56 | @ | Memphis | 17 | CUSA | |||
| 11/5/2010 | UCF | 40 | @ | Houston | 33 | CUSA | |||
| 11/13/2010 | Tulsa | 28 | @ | Houston | 25 | CUSA | |||
| 11/20/2010 | Houston | 41 | @ | Southern Miss | 59 | CUSA | |||
| 11/27/2010 | Houston | 20 | @ | Texas Tech | 35 |