| 9/11/2010 | Rutgers | 19 | @ | Florida Intl | 14 | ||||
| 9/18/2010 | Florida Intl | 20 | @ | Texas A&M | 27 | ||||
| 9/25/2010 | Florida Intl | 28 | @ | Maryland | 42 | ||||
| 10/2/2010 | Florida Intl | 17 | @ | Pittsburgh | 44 | ||||
| 10/9/2010 | Western Kentucky | 21 | @ | Florida Intl | 28 | SBC | |||
| 10/16/2010 | Florida Intl | 34 | @ | North Texas | 10 | SBC | |||
| 10/30/2010 | Florida Intl | 9 | @ | Florida Atlantic | 21 | SBC | |||
| 11/6/2010 | UL Monroe | 35 | @ | Florida Intl | 42 | 2 OT | SBC | ||
| 11/13/2010 | Florida Intl | 52 | @ | Troy | 35 | SBC | |||
| 11/20/2010 | Florida Intl | 38 | @ | UL Lafayette | 17 | SBC | |||
| 11/27/2010 | Arkansas State | 24 | @ | Florida Intl | 31 | SBC | |||
| 12/4/2010 | Middle Tenn State | 28 | @ | Florida Intl | 27 | SBC | |||
| 12/26/2010 | Florida Intl | 34 | vs | Toledo | 32 | Detroit - Little Ceasar's Bowl |