| 9/4/2010 | Arkansas State | 26 | @ | Auburn | 52 | ||||
| 9/11/2010 | Arkansas State | 24 | @ | UL Lafayette | 31 | SBC | |||
| 9/18/2010 | UL Monroe | 20 | @ | Arkansas State | 34 | SBC | |||
| 9/25/2010 | Arkansas State | 28 | @ | Troy | 35 | SBC | |||
| 10/2/2010 | Louisville | 34 | @ | Arkansas State | 24 | ||||
| 10/9/2010 | Arkansas State | 24 | @ | North Texas | 19 | SBC | |||
| 10/16/2010 | Arkansas State | 34 | @ | Indiana | 36 | ||||
| 10/23/2010 | Florida Atlantic | 16 | @ | Arkansas State | 37 | SBC | |||
| 11/2/2010 | Middle Tenn State | 24 | @ | Arkansas State | 51 | SBC | |||
| 11/13/2010 | Western Kentucky | 36 | @ | Arkansas State | 35 | OT | SBC | ||
| 11/20/2010 | Arkansas State | 19 | @ | Navy | 35 | ||||
| 11/27/2010 | Arkansas State | 24 | @ | Florida Intl | 31 | SBC |