| 9/2/2010 | Pittsburgh | 24 | @ | Utah | 27 | OT | |||
| 9/11/2010 | New Hampshire 1AA | 16 | @ | Pittsburgh | 38 | ||||
| 9/23/2010 | Miami-Florida | 31 | @ | Pittsburgh | 3 | ||||
| 10/2/2010 | Florida Intl | 17 | @ | Pittsburgh | 44 | ||||
| 10/9/2010 | Pittsburgh | 17 | @ | Notre Dame | 23 | ||||
| 10/16/2010 | Pittsburgh | 45 | @ | Syracuse | 14 | BigE | |||
| 10/23/2010 | Rutgers | 21 | @ | Pittsburgh | 41 | BigE | |||
| 10/30/2010 | Louisville | 3 | @ | Pittsburgh | 21 | BigE | |||
| 11/11/2010 | Pittsburgh | 28 | @ | Connecticut | 30 | BigE | |||
| 11/20/2010 | Pittsburgh | 17 | @ | South Florida | 10 | BigE | |||
| 11/26/2010 | West Virginia | 35 | @ | Pittsburgh | 10 | BigE | |||
| 12/4/2010 | Pittsburgh | 28 | @ | Cincinnati | 10 | BigE | |||
| 1/8/2011 | Pittsburgh | 27 | vs | Kentucky | 10 | Birmingham - BBVA Compass Bowl |