| 9/4/2010 | Bowling Green | 27 | @ | Troy | 30 | ||||
| 9/11/2010 | Troy | 38 | @ | Oklahoma State | 41 | ||||
| 9/18/2010 | Troy | 33 | @ | UAB | 34 | ||||
| 9/25/2010 | Arkansas State | 28 | @ | Troy | 35 | SBC | |||
| 10/5/2010 | Troy | 42 | @ | Middle Tenn State | 13 | SBC | |||
| 10/16/2010 | UL Lafayette | 24 | @ | Troy | 31 | SBC | |||
| 10/30/2010 | Troy | 14 | @ | UL Monroe | 28 | SBC | |||
| 11/6/2010 | Troy | 41 | @ | North Texas | 35 | SBC | |||
| 11/13/2010 | Florida Intl | 52 | @ | Troy | 35 | SBC | |||
| 11/20/2010 | Troy | 24 | @ | South Carolina | 69 | ||||
| 11/27/2010 | Western Kentucky | 14 | @ | Troy | 28 | SBC | |||
| 12/4/2010 | Troy | 44 | @ | Florida Atlantic | 7 | SBC | |||
| 12/18/2010 | Ohio | 21 | vs | Troy | 48 | New Orleans - New Orleans Bowl |