| 9/2/2010 | Minnesota | 24 | @ | Middle Tenn State | 17 | ||||
| 9/11/2010 | Austin Peay 1AA | 33 | @ | Middle Tenn State | 56 | ||||
| 9/18/2010 | Middle Tenn State | 17 | @ | Memphis | 24 | ||||
| 9/25/2010 | Middle Tenn State | 34 | @ | UL Lafayette | 14 | SBC | |||
| 10/5/2010 | Troy | 42 | @ | Middle Tenn State | 13 | SBC | |||
| 10/16/2010 | Middle Tenn State | 14 | @ | Georgia Tech | 42 | ||||
| 10/23/2010 | UL Monroe | 10 | @ | Middle Tenn State | 38 | SBC | |||
| 11/2/2010 | Middle Tenn State | 24 | @ | Arkansas State | 51 | SBC | |||
| 11/13/2010 | North Texas | 23 | @ | Middle Tenn State | 17 | SBC | |||
| 11/20/2010 | Middle Tenn State | 27 | @ | Western Kentucky | 26 | SBC | |||
| 11/27/2010 | Florida Atlantic | 14 | @ | Middle Tenn State | 38 | SBC | |||
| 12/4/2010 | Middle Tenn State | 28 | @ | Florida Intl | 27 | SBC | |||
| 1/6/2011 | Middle Tenn State | 21 | vs | Miami-Ohio | 35 | Mobile - GoDaddy.com Bowl |