| 8/28/2010 | Truman State @ St Joseph's | |
| 9/2/2010 | Indianapolis @ Kentucky Wesleyan | |
| 9/4/2010 | West Virginia State vs Central State | |
| 9/4/2010 | Missouri S&T @ Emporia State | |
| 9/4/2010 | St Joseph's @ Indiana State | |
| 9/4/2010 | Urbana @ West Virginia Wesleyan | |
| 9/11/2010 | Central State @ Alabama A&M | |
| 9/11/2010 | Pikeville @ Kentucky Wesleyan | |
| 9/11/2010 | Drake @ Missouri S&T | |
| 9/11/2010 | St Joseph's @ Shepherd | |
| 9/11/2010 | Seton Hill @ Urbana | |
| 9/18/2010 | Kentucky Wesleyan @ Central State | † |
| 9/18/2010 | Urbana @ Tusculum | |
| 9/18/2010 | Missouri S&T @ Wisconsin-Stevens Point | |
| 9/18/2010 | St Joseph's @ Valparaiso | |
| 9/25/2010 | Central State @ Dayton | |
| 9/25/2010 | Alma @ Kentucky Wesleyan | |
| 9/25/2010 | Wisconsin-La Crosse @ Missouri S&T | |
| 9/25/2010 | Urbana @ Walsh | |
| 10/2/2010 | Notre Dame OH @ Central State | |
| 10/2/2010 | St Joseph's @ Lincoln MO | |
| 10/2/2010 | Northwestern Oklahoma State @ Missouri S&T | |
| 10/2/2010 | Kentucky Wesleyan @ South Alabama | |
| 10/2/2010 | Southwest Baptist @ Urbana | |
| 10/9/2010 | Kentucky State @ Central State | |
| 10/9/2010 | Missouri S&T @ South Alabama | |
| 10/9/2010 | Notre Dame OH @ St Joseph's | |
| 10/9/2010 | Kentucky Wesleyan @ Urbana | † |
| 10/16/2010 | St Augustine's @ Central State | |
| 10/16/2010 | Kentucky Wesleyan @ Missouri S&T | † |
| 10/16/2010 | Urbana @ St Joseph's | † |
| 10/23/2010 | St Joseph's @ Kentucky Wesleyan | † |
| 10/23/2010 | Missouri S&T @ St Francis IN | |
| 10/23/2010 | Central State @ Southwest Baptist | |
| 10/23/2010 | Charleston WV @ Urbana | |
| 10/30/2010 | Central State @ Lambuth | |
| 10/30/2010 | Urbana @ Missouri S&T | † |
| 10/30/2010 | St Joseph's @ Southwest Baptist | |
| 11/6/2010 | Notre Dame OH @ Kentucky Wesleyan | |
| 11/6/2010 | Missouri S&T @ St Joseph's | † |
| 11/6/2010 | Central State @ Urbana | † |
| 11/13/2010 | Kentucky Wesleyan @ Concordia AL | |
| 11/13/2010 | Missouri S&T @ Lincoln MO | |
| 11/13/2010 | Urbana @ Notre Dame OH | |
| 11/13/2010 | Central State @ Stillman |