| 9/2/2010 | Indianapolis 38 @ Kentucky Wesleyan Panthers 10 | |
| 9/11/2010 | Ashland Eagles 12 @ Indianapolis 17 | † |
| 9/18/2010 | Indianapolis 31 @ Grand Valley State Lakers 38 | † |
| 9/25/2010 | Michigan Tech Huskies 24 @ Indianapolis 10 | † |
| 10/2/2010 | Indianapolis 20 @ Findlay Oilers 3 | † |
| 10/9/2010 | Northwood Timberwolves 31 @ Indianapolis 24 | † |
| 10/16/2010 | Indianapolis 20 @ Saginaw Valley State Cardinals 24 | † |
| 10/23/2010 | Indianapolis 6 @ Northern Michigan Wildcats 5 | † |
| 10/30/2010 | Ferris State Bulldogs 33 @ Indianapolis 37 | † |
| 11/6/2010 | Indianapolis 27 @ Wayne State MI Warriors 41 | † |
| 11/13/2010 | Ohio Dominican Panthers 17 @ Indianapolis 31 | † |