| 8/28/2010 | Truman State 23 @ St Joseph's Pumas 13 | |
| 9/4/2010 | Southwest Baptist Bearcats 30 @ Truman State 33 | |
| 9/18/2010 | Truman State 9 @ Fort Hays State Tigers 34 | † |
| 9/25/2010 | Northwest Missouri State Bearcats 44 @ Truman State 10 | † |
| 10/2/2010 | Central Missouri Mules 38 @ Truman State 14 | † |
| 10/9/2010 | Truman State 7 @ Missouri Western Griffons 29 | † |
| 10/16/2010 | Missouri Southern Lions 6 @ Truman State 23 | † |
| 10/23/2010 | Truman State 37 @ Emporia State Hornets 34 | † |
| 10/30/2010 | Washburn Ichabods 45 @ Truman State 12 | † |
| 11/6/2010 | Truman State 14 @ Pittsburg State Gorillas 17 | † |
| 11/13/2010 | Nebraska-Omaha Mavericks 62 @ Truman State 61 | † |