| 8/28/2010 | Albany State GA Golden Rams 42 @ Kentucky State 12 | † |
| 9/4/2010 | Lane Dragons 14 vs Kentucky State 27 (Lexington KY) | † |
| 9/11/2010 | Kentucky State 26 vs Benedict Tigers 21 (Augusta GA) | † |
| 9/18/2010 | Kentucky State 25 @ Morehouse Maroon Tigers 41 | † |
| 9/25/2010 | Kentucky State 12 @ Miles Golden Bears 13 | † |
| 10/2/2010 | Kentucky State 7 @ Eastern Kentucky Colonels 58 | |
| 10/9/2010 | Kentucky State 41 @ Central State Marauders 24 | |
| 10/16/2010 | Clark Atlanta Panthers 19 @ Kentucky State 7 | † |
| 10/23/2010 | Fort Valley State Wildcats 14 @ Kentucky State 12 | † |
| 10/30/2010 | Kentucky State 21 @ Tuskegee Golden Tigers 45 | † |
| 11/6/2010 | Kentucky State 12 @ Stillman Tigers 23 | † |