| 9/4/2010 | Lehigh Mountain Hawks 28 @ Drake 14 | |
| 9/11/2010 | Drake 28 @ Missouri S&T Miners 14 | |
| 9/18/2010 | Drake 21 @ Montana State Bobcats 48 | |
| 9/25/2010 | Drake 21 @ Valparaiso Crusaders 19 | † |
| 10/2/2010 | Marist Red Foxes 0 @ Drake 42 | † |
| 10/9/2010 | Drake 34 @ Jacksonville Dolphins 39 | † |
| 10/16/2010 | Drake 14 @ Campbell Camels 12 | † |
| 10/23/2010 | Davidson Wildcats 10 @ Drake 42 | † |
| 10/30/2010 | San Diego Toreros 17 @ Drake 38 | † |
| 11/6/2010 | Drake 25 @ Dayton Flyers 31 | † |
| 11/13/2010 | Butler Bulldogs 7 @ Drake 10 | † |