| 8/28/2010 | Bowie State Bulldogs 14 @ Seton Hill 20 | |
| 9/4/2010 | New Haven Chargers 34 @ Seton Hill 17 | |
| 9/11/2010 | Seton Hill 13 @ Urbana Blue Knights 44 | |
| 9/18/2010 | Seton Hill 28 @ Glenville State Pioneers 38 | † |
| 9/25/2010 | Shepherd Rams 46 @ Seton Hill 17 | † |
| 10/2/2010 | Seton Hill 16 @ West Virginia Wesleyan Bobcats 37 | † |
| 10/9/2010 | West Virginia State Yellow Jackets 20 @ Seton Hill 48 | † |
| 10/16/2010 | Seton Hill 20 @ Charleston WV Golden Eagles 24 | † |
| 10/23/2010 | Concord Mountain Lions 28 @ Seton Hill 17 | † |
| 10/30/2010 | Seton Hill 29 @ Fairmont State Falcons 44 | † |
| 11/6/2010 | West Liberty Hilltoppers 82 @ Seton Hill 36 | † |