| 9/2/2010 | Valparaiso 0 @ Western Illinois Leathernecks 45 | |
| 9/11/2010 | Valparaiso 7 @ Franklin Grizzlies 42 | |
| 9/18/2010 | St Joseph's Pumas 50 @ Valparaiso 7 | |
| 9/25/2010 | Drake Bulldogs 21 @ Valparaiso 19 | † |
| 10/2/2010 | Valparaiso 14 @ Dayton Flyers 48 | † |
| 10/9/2010 | Marist Red Foxes 51 @ Valparaiso 7 | † |
| 10/16/2010 | Jacksonville Dolphins 86 @ Valparaiso 7 | † |
| 10/23/2010 | Valparaiso 10 @ San Diego Toreros 30 | † |
| 10/30/2010 | Butler Bulldogs 48 @ Valparaiso 0 | † |
| 11/6/2010 | Valparaiso 14 @ Campbell Camels 56 | † |
| 11/13/2010 | Valparaiso 15 @ Morehead State Eagles 37 | † |