| 9/4/2010 | Heidelberg Fighting Student Princes 42 @ Alma 23 | |
| 9/11/2010 | Alma 14 @ Illinois Wesleyan Titans 35 | |
| 9/18/2010 | Rockford Regents 10 @ Alma 27 | |
| 9/25/2010 | Alma 28 @ Kentucky Wesleyan Panthers 49 | |
| 10/2/2010 | Alma 0 @ Hope Flying Dutchmen 38 | † |
| 10/9/2010 | Albion Britons 27 @ Alma 17 | † |
| 10/16/2010 | Alma 0 @ Trine Thunder 38 | † |
| 10/30/2010 | Kalamazoo Hornets 10 @ Alma 35 | † |
| 11/6/2010 | Alma 35 @ Olivet Comets 21 | † |
| 11/13/2010 | Adrian Bulldogs 24 @ Alma 13 | † |