| 9/2/2021 | Texas College | 0 | at | West Texas A&M (7-4) | 73 | at LSC | ||
| 9/11/2021 | Texas College | 6 | at | Langston (7-3,6-3) | 44 | |||
| 9/18/2021 | Panhandle State (4-7,3-6) | 68 | at | Texas College | 0 | |||
| 9/25/2021 | Wayland Baptist (2-8,2-7) | 38 | at | Texas College | 18 | |||
| 10/2/2021 | Texas College | 0 | at | Lane (6-4) | 71 | at SIAC | ||
| 10/9/2021 | Ottawa AZ (8-2,8-1) | 48 | at | Texas College | 6 | |||
| 10/16/2021 | Lyon (2-8,2-7) | 33 | at | Texas College | 32 | |||
| 10/23/2021 | Texas College | 16 | at | Arizona Christian (8-2,7-2) | 64 | |||
| 10/30/2021 | Texas College | 18 | at | Texas Wesleyan (7-3,7-2) | 69 | |||
| 11/6/2021 | Southwestern Assemblies of God (9-3,6-3) | 63 | at | Texas College | 0 | |||
| 11/13/2021 | Texas College | 12 | at | Louisiana College (4-7,4-5) | 77 |
| vs Texas College | vs Other Opponents | Texas College compared to OOs | |
| Record: | 11-0 | 53-51 | |
| Points Scored: | 58.91 | 31.69 | -27.22 |
| Points Allowed: | 9.82 | 31.41 | -21.59 |
| Margin: | 49.09 | 0.28 | -48.81 |
| Total Points: | 68.73 | 63.10 | 5.63 |