| 9/2/2021 | Texas College (0-11) | 0 | at | West Texas A&M | 73 | Soon (NAIA) | ||
| 9/11/2021 | West Texas A&M | 31 | at | Texas-Permian Basin (5-6,3-4) | 42 | |||
| 9/18/2021 | Western New Mexico (1-9,0-7) | 14 | at | West Texas A&M | 42 | |||
| 9/25/2021 | Colorado Mines (12-2) | 21 | at | West Texas A&M | 13 | RMAC | ||
| 10/2/2021 | West Texas A&M | 38 | at | Western Oregon (4-6) | 41 | at GNWAC | ||
| 10/9/2021 | Angelo State (11-3,5-2) | 15 | at | West Texas A&M | 31 | |||
| 10/16/2021 | West Texas A&M | 44 | at | Eastern New Mexico (4-7,1-6) | 24 | |||
| 10/23/2021 | Texas A&M-Commerce (7-4,5-2) | 15 | at | West Texas A&M | 3 | |||
| 10/30/2021 | West Texas A&M | 35 | at | Texas A&M-Kingsville (5-5,3-4) | 23 | |||
| 11/6/2021 | Midwestern State (7-3,6-1) | 12 | at | West Texas A&M | 15 | |||
| 11/13/2021 | Bethel KS (9-2) | 9 | at | West Texas A&M | 52 | KCAC (NAIA) |
| vs West Texas A&M | vs Other Opponents | West Texas A&M compared to OOs | |
| Record: | 4-7 | 61-51 | |
| Points Scored: | 19.64 | 29.76 | 10.12 |
| Points Allowed: | 34.27 | 26.46 | 7.81 |
| Margin: | -14.63 | 3.30 | 17.93 |
| Total Points: | 53.91 | 56.22 | -2.31 |