| 9/4/2021 | Wayland Baptist | 0 | at | Hardin-Simmons (9-1) | 49 | at ASWC | ||
| 9/11/2021 | Wayland Baptist | 31 | at | Lyon (2-8,2-7) | 7 | |||
| 9/18/2021 | Langston (7-3,6-3) | 50 | at | Wayland Baptist | 0 | |||
| 9/25/2021 | Wayland Baptist | 38 | at | Texas College (0-11,0-9) | 18 | |||
| 10/2/2021 | Wayland Baptist | 7 | at | Texas Wesleyan (7-3,7-2) | 63 | |||
| 10/9/2021 | Panhandle State (4-7,3-6) | 20 | at | Wayland Baptist | 13 | |||
| 10/16/2021 | Louisiana College (4-7,4-5) | 27 | at | Wayland Baptist | 24 | |||
| 10/30/2021 | Wayland Baptist | 29 | at | Southwestern Assemblies of God (9-3,6-3) | 54 | |||
| 11/6/2021 | Ottawa AZ (8-2,8-1) | 61 | at | Wayland Baptist | 30 | |||
| 11/13/2021 | Wayland Baptist | 16 | at | Arizona Christian (8-2,7-2) | 54 |
| vs Wayland Baptist | vs Other Opponents | Wayland Baptist compared to OOs | |
| Record: | 8-2 | 50-45 | |
| Points Scored: | 40.30 | 33.57 | -6.73 |
| Points Allowed: | 18.80 | 32.16 | -13.36 |
| Margin: | 21.50 | 1.41 | -20.09 |
| Total Points: | 59.10 | 65.73 | -6.63 |