| 9/4/2021 | Lane | 16 | at | Ark Pine Bluff (2-9) | 34 | at SWAC | ||
| 9/11/2021 | Lane | 35 | at | Clark Atlanta (2-8,1-7) | 26 | |||
| 9/18/2021 | Lane | 27 | at | Fort Valley State (5-5,5-4) | 24 | |||
| 9/25/2021 | Lane | 45 | at | Edward Waters (4-7,3-7) | 35 | |||
| 10/2/2021 | Texas College (0-11) | 0 | at | Lane | 71 | Soon (NAIA) | ||
| 10/9/2021 | Lane | 14 | at | Kentucky State (7-4,6-2) | 49 | |||
| 10/16/2021 | Miles (6-5,6-3) | 34 | at | Lane | 31 | |||
| 10/23/2021 | Lane | 21 | at | Tuskegee (3-8,3-5) | 17 | |||
| 10/30/2021 | Lane | 16 | at | Central State (1-9,0-8) | 14 | |||
| 11/6/2021 | Lane | 30 | at | Benedict (5-5,5-5) | 34 |
| vs Lane | vs Other Opponents | Lane compared to OOs | |
| Record: | 4-6 | 31-65 | |
| Points Scored: | 26.70 | 20.27 | -6.43 |
| Points Allowed: | 30.60 | 32.01 | -1.41 |
| Margin: | -3.90 | -11.74 | -7.84 |
| Total Points: | 57.30 | 52.28 | 5.02 |