| 8/28/2021 | Lyon | 14 | at | Missouri Baptist (4-7) | 31 | at MSFA | ||
| 9/4/2021 | Lyon | 10 | at | Ottawa AZ (8-2,8-1) | 76 | |||
| 9/11/2021 | Wayland Baptist (2-8,2-7) | 31 | at | Lyon | 7 | |||
| 9/25/2021 | Lyon | 6 | at | Panhandle State (4-7,3-6) | 35 | |||
| 10/2/2021 | Langston (7-3,6-3) | 30 | at | Lyon | 0 | |||
| 10/9/2021 | Arizona Christian (8-2,7-2) | 55 | at | Lyon | 21 | |||
| 10/16/2021 | Lyon | 33 | at | Texas College (0-11,0-9) | 32 | |||
| 10/23/2021 | Lyon | 21 | at | Southwestern Assemblies of God (9-3,6-3) | 38 | |||
| 11/6/2021 | Louisiana College (4-7,4-5) | 33 | at | Lyon | 35 | |||
| 11/13/2021 | Texas Wesleyan (7-3,7-2) | 48 | vs | Lyon | 13 |
| vs Lyon | vs Other Opponents | Lyon compared to OOs | |
| Record: | 8-2 | 45-51 | |
| Points Scored: | 40.90 | 31.57 | -9.33 |
| Points Allowed: | 16.00 | 34.01 | -18.01 |
| Margin: | 24.90 | -2.44 | -27.34 |
| Total Points: | 56.90 | 65.58 | -8.68 |