| 9/3/2015 | TCU | 23 | at | Minnesota | 17 | B12 | ||
| Michigan | 17 | at | Utah | 24 | @ P12 | |||
| 9/4/2015 | Michigan State | 37 | at | Western Michigan | 24 | @ MAC | ||
| 9/5/2015 | Wisconsin | 17 | vs | Alabama | 35 | Arlington TX | vs SEC | |
| Kent State | 3 | at | Illinois | 52 | MAC | |||
| Southern Illinois | 47 | at | Indiana | 48 | MVC (1AA) | |||
| Illinois State | 14 | at | Iowa | 31 | MVC (1AA) | |||
| Richmond | 21 | at | Maryland | 50 | CAAF (1AA) | |||
| BYU | 33 | at | Nebraska | 28 | Ind | |||
| Stanford | 6 | at | Northwestern | 16 | P12 | |||
| Norfolk State | 13 | at | Rutgers | 63 | MEAC (1AA) | |||
| Penn State | 10 | at | Temple | 27 | @ AAC | |||
| 9/6/2015 | Purdue | 31 | at | Marshall | 41 | @ CUSA | ||
| 9/7/2015 | Ohio State | 42 | at | Virginia Tech | 24 | @ ACC | ||
| 9/12/2015 | Minnesota | 23 | at | Colorado State | 20 | OT | @ MW | |
| Western Illinois | 0 | at | Illinois | 44 | MVC (1AA) | |||
| Florida Intl | 22 | at | Indiana | 36 | CUSA | |||
| Iowa | 31 | at | Iowa State | 17 | @ B12 | |||
| Bowling Green | 48 | at | Maryland | 27 | MAC | |||
| Oregon State | 7 | at | Michigan | 35 | P12 | |||
| Oregon | 28 | at | Michigan State | 31 | P12 | |||
| South Alabama | 9 | at | Nebraska | 48 | SBC | |||
| Eastern Illinois | 0 | at | Northwestern | 41 | OVC (1AA) | |||
| Hawaii | 0 | at | Ohio State | 38 | MW | |||
| Buffalo | 14 | at | Penn State | 27 | MAC | |||
| Indiana State | 14 | at | Purdue | 38 | MVC (1AA) | |||
| Washington State | 37 | at | Rutgers | 34 | P12 | |||
| Miami-Ohio | 0 | at | Wisconsin | 58 | MAC | |||
| 9/19/2015 | Northwestern | 19 | at | Duke | 10 | @ ACC | ||
| Western Kentucky | 35 | at | Indiana | 38 | CUSA | |||
| Pittsburgh | 24 | at | Iowa | 27 | ACC | |||
| South Florida | 17 | at | Maryland | 35 | AAC | |||
| Nebraska | 33 | at | Miami-Florida | 36 | OT | @ ACC | ||
| UNLV | 7 | at | Michigan | 28 | MW | |||
| Air Force | 21 | at | Michigan State | 35 | MW | |||
| Kent State | 7 | at | Minnesota | 10 | MAC | |||
| Illinois | 14 | at | North Carolina | 48 | @ ACC | |||
| Northern Illinois | 13 | at | Ohio State | 20 | MAC | |||
| Rutgers | 3 | at | Penn State | 28 | ||||
| Virginia Tech | 51 | at | Purdue | 24 | ACC | |||
| Troy | 3 | at | Wisconsin | 28 | SBC | |||
| 9/26/2015 | Middle Tenn State | 25 | at | Illinois | 27 | CUSA | ||
| North Texas | 16 | at | Iowa | 62 | CUSA | |||
| BYU | 0 | at | Michigan | 31 | Ind | |||
| Central Michigan | 10 | at | Michigan State | 30 | MAC | |||
| Ohio | 24 | at | Minnesota | 27 | MAC | |||
| Southern Miss | 28 | at | Nebraska | 36 | CUSA | |||
| Ball State | 19 | at | Northwestern | 24 | MAC | |||
| Western Michigan | 12 | at | Ohio State | 38 | MAC | |||
| San Diego State | 21 | at | Penn State | 37 | MW | |||
| Bowling Green | 35 | at | Purdue | 28 | MAC | |||
| Kansas | 14 | at | Rutgers | 27 | B12 | |||
| Indiana | 31 | at | Wake Forest | 24 | @ ACC | |||
| Maryland | 6 | at | West Virginia | 45 | @ B12 | |||
| Hawaii | 0 | at | Wisconsin | 28 | MW | |||
| 10/3/2015 | Nebraska | 13 | at | Illinois | 14 | |||
| Ohio State | 34 | at | Indiana | 27 | ||||
| Michigan | 28 | at | Maryland | 0 | ||||
| Purdue | 21 | at | Michigan State | 24 | ||||
| Minnesota | 0 | at | Northwestern | 27 | ||||
| Army | 14 | at | Penn State | 20 | Ind | |||
| Iowa | 10 | at | Wisconsin | 6 | ||||
| 10/10/2015 | Illinois | 20 | at | Iowa | 29 | |||
| Northwestern | 0 | at | Michigan | 38 | ||||
| Wisconsin | 23 | at | Nebraska | 21 | ||||
| Maryland | 28 | at | Ohio State | 49 | ||||
| Indiana | 7 | at | Penn State | 29 | ||||
| Minnesota | 41 | at | Purdue | 13 | ||||
| Michigan State | 31 | at | Rutgers | 24 | ||||
| 10/17/2015 | Rutgers | 55 | at | Indiana | 52 | |||
| Michigan State | 27 | at | Michigan | 23 | ||||
| Nebraska | 48 | at | Minnesota | 25 | ||||
| Iowa | 40 | at | Northwestern | 10 | ||||
| Penn State | 10 | at | Ohio State | 38 | ||||
| Purdue | 7 | at | Wisconsin | 24 | ||||
| 10/24/2015 | Wisconsin | 24 | at | Illinois | 13 | |||
| Penn State | 31 | at | Maryland | 30 | ||||
| Indiana | 26 | at | Michigan State | 52 | ||||
| Northwestern | 30 | at | Nebraska | 28 | ||||
| Ohio State | 49 | at | Rutgers | 7 | ||||
| 10/31/2015 | Maryland | 15 | at | Iowa | 31 | |||
| Michigan | 29 | at | Minnesota | 26 | ||||
| Illinois | 0 | at | Penn State | 39 | ||||
| Nebraska | 45 | at | Purdue | 55 | ||||
| Rutgers | 10 | at | Wisconsin | 48 | ||||
| 11/7/2015 | Iowa | 35 | at | Indiana | 27 | |||
| Wisconsin | 31 | at | Maryland | 24 | ||||
| Rutgers | 16 | at | Michigan | 49 | ||||
| Michigan State | 38 | at | Nebraska | 39 | ||||
| Penn State | 21 | at | Northwestern | 23 | ||||
| Minnesota | 14 | at | Ohio State | 28 | ||||
| Illinois | 48 | at | Purdue | 14 | ||||
| 11/14/2015 | Ohio State | 28 | at | Illinois | 3 | |||
| Michigan | 48 | at | Indiana | 41 | 2OT | |||
| Minnesota | 35 | at | Iowa | 40 | ||||
| Maryland | 7 | at | Michigan State | 24 | ||||
| Purdue | 14 | at | Northwestern | 21 | ||||
| Nebraska | 31 | at | Rutgers | 14 | ||||
| 11/21/2015 | Rutgers | 31 | at | Army | 21 | @ Ind | ||
| Purdue | 20 | at | Iowa | 40 | ||||
| Indiana | 47 | at | Maryland | 28 | ||||
| Illinois | 23 | at | Minnesota | 32 | ||||
| Michigan State | 17 | at | Ohio State | 14 | ||||
| Michigan | 28 | at | Penn State | 16 | ||||
| Northwestern | 13 | at | Wisconsin | 7 | ||||
| 11/27/2015 | Iowa | 28 | at | Nebraska | 20 | |||
| 11/28/2015 | Northwestern | 24 | vs | Illinois | 14 | Chicago IL | ||
| Ohio State | 42 | at | Michigan | 13 | ||||
| Penn State | 16 | at | Michigan State | 55 | ||||
| Wisconsin | 31 | at | Minnesota | 21 | ||||
| Indiana | 54 | at | Purdue | 36 | ||||
| Maryland | 46 | at | Rutgers | 41 | ||||
| 12/5/2015 | Michigan State | 16 | vs | Iowa | 13 | B10 Championship (Indianapolis IN) | ||
| 12/26/2015 | Indiana | 41 | vs | Duke | 44 | OT | Pinstripe Bowl (New York NY) | vs ACC |
| UCLA | 29 | vs | Nebraska | 37 | Foster Farms Bowl (Santa Clara CA) | vs P12 | ||
| 12/28/2015 | Central Michigan | 14 | vs | Minnesota | 21 | Quick Lane Bowl (Detroit MI) | vs MAC | |
| 12/30/2015 | Southern California | 21 | vs | Wisconsin | 23 | Holiday Bowl (San Diego CA) | vs P12 | |
| 12/31/2015 | Michigan State | 0 | vs | Alabama | 38 | Cotton Bowl (Arlington TX) | vs SEC | |
| 1/1/2016 | Michigan | 41 | vs | Florida | 7 | Citrus Bowl (Orlando FL) | vs SEC | |
| Stanford | 45 | vs | Iowa | 16 | Rose Bowl (Pasadena CA) | vs P12 | ||
| Notre Dame | 28 | vs | Ohio State | 44 | Fiesta Bowl (Glendale AZ) | vs ND | ||
| Northwestern | 6 | vs | Tennessee | 45 | Outback Bowl (Tampa FL) | vs SEC | ||
| 1/2/2016 | Penn State | 17 | vs | Georgia | 24 | Taxslayer Bowl (Jacksonville FL) | vs SEC |