| 9/3/2015 | Ohio | 45 | at | Idaho (4-8) | 28 | at SBC | ||
| 9/12/2015 | Marshall (10-3) | 10 | at | Ohio | 21 | CUSA | ||
| 9/19/2015 | Southeastern Louisiana (4-7) | 14 | at | Ohio | 35 | SLC (1AA) | ||
| 9/26/2015 | Ohio | 24 | at | Minnesota (6-7) | 27 | at B10 | ||
| 10/3/2015 | Ohio | 14 | at | Akron (8-5,5-3) | 12 | |||
| 10/10/2015 | Miami-Ohio (3-9,2-6) | 3 | at | Ohio | 34 | |||
| 10/17/2015 | Western Michigan (8-5,6-2) | 49 | at | Ohio | 14 | |||
| 10/24/2015 | Ohio | 17 | at | Buffalo (5-7,3-5) | 41 | |||
| 11/4/2015 | Ohio | 24 | at | Bowling Green (10-4,8-1) | 62 | |||
| 11/10/2015 | Kent State (3-9,2-6) | 0 | at | Ohio | 27 | |||
| 11/17/2015 | Ball State (3-9,2-6) | 31 | at | Ohio | 48 | |||
| 11/24/2015 | Ohio | 26 | at | Northern Illinois (8-6,6-3) | 21 | |||
| 12/19/2015 | Ohio | 29 | vs | Appalachian State (11-2) | 31 | Camellia Bowl (Montgomery AL) | vs SBC |
| vs Ohio | vs Other Opponents | Ohio compared to OOs | |
| Record: | 5-8 | 78-73 | |
| Points Scored: | 25.31 | 27.86 | 2.55 |
| Points Allowed: | 27.54 | 27.09 | 0.45 |
| Margin: | -2.23 | 0.77 | 3.00 |
| Total Points: | 52.85 | 54.95 | -2.10 |