| 9/5/2015 | Northern Iowa (9-5) | 7 | at | Iowa State | 31 | MVC (1AA) | ||
| 9/12/2015 | Iowa (12-2) | 31 | at | Iowa State | 17 | B10 | ||
| 9/19/2015 | Iowa State | 23 | at | Toledo (10-2) | 30 | OT | at MAC | |
| 10/3/2015 | Kansas (0-12,0-9) | 13 | at | Iowa State | 38 | |||
| 10/10/2015 | Iowa State | 31 | at | Texas Tech (7-6,4-5) | 66 | |||
| 10/17/2015 | TCU (11-2,7-2) | 45 | at | Iowa State | 21 | |||
| 10/24/2015 | Iowa State | 27 | at | Baylor (10-3,6-3) | 45 | |||
| 10/31/2015 | Texas (5-7,4-5) | 0 | at | Iowa State | 24 | |||
| 11/7/2015 | Iowa State | 16 | at | Oklahoma (11-2,8-1) | 52 | |||
| 11/14/2015 | Oklahoma State (10-3,7-2) | 35 | at | Iowa State | 31 | |||
| 11/21/2015 | Iowa State | 35 | at | Kansas State (6-7,3-6) | 38 | |||
| 11/28/2015 | Iowa State | 6 | at | West Virginia (8-5,4-5) | 30 |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 9-3 | 90-53 | |
| Points Scored: | 32.67 | 35.22 | 2.55 |
| Points Allowed: | 25.00 | 28.80 | -3.80 |
| Margin: | 7.67 | 6.42 | -1.25 |
| Total Points: | 57.67 | 64.02 | -6.35 |