| 9/5/2015 | UNLV (3-9) | 30 | at | Northern Illinois | 38 | MW | ||
| 9/12/2015 | Murray State (3-8) | 26 | at | Northern Illinois | 57 | OVC (1AA) | ||
| 9/19/2015 | Northern Illinois | 13 | at | Ohio State (12-1) | 20 | at B10 | ||
| 9/26/2015 | Northern Illinois | 14 | at | Boston College (3-9) | 17 | at ACC | ||
| 10/3/2015 | Northern Illinois | 19 | at | Central Michigan (7-6,6-2) | 29 | |||
| 10/10/2015 | Ball State (3-9,2-6) | 41 | at | Northern Illinois | 59 | |||
| 10/17/2015 | Northern Illinois | 45 | at | Miami-Ohio (3-9,2-6) | 12 | |||
| 10/24/2015 | Eastern Michigan (1-11,0-8) | 21 | at | Northern Illinois | 49 | |||
| 11/3/2015 | Northern Illinois | 32 | at | Toledo (10-2,6-2) | 27 | |||
| 11/11/2015 | Northern Illinois | 41 | at | Buffalo (5-7,3-5) | 30 | |||
| 11/18/2015 | Western Michigan (8-5,6-2) | 19 | at | Northern Illinois | 27 | |||
| 11/24/2015 | Ohio (8-5,5-3) | 26 | at | Northern Illinois | 21 | |||
| 12/4/2015 | Bowling Green (10-4,8-1) | 34 | vs | Northern Illinois | 14 | MAC Championship (Detroit MI) | ||
| 12/23/2015 | Boise State (9-4) | 55 | vs | Northern Illinois | 7 | Poinsettia Bowl (San Diego CA) | MW |
| vs Northern Illinois | vs Other Opponents | Northern Illinois compared to OOs | |
| Record: | 6-8 | 79-81 | |
| Points Scored: | 27.64 | 29.75 | 2.11 |
| Points Allowed: | 31.14 | 26.91 | 4.23 |
| Margin: | -3.50 | 2.84 | 6.34 |
| Total Points: | 58.78 | 56.66 | 2.12 |